From a timing standpoint, this loss hurts the most. It was a road game though, and if you don't bring it, this is what happens.
BUT this was far from the worst loss of the year. The Mizzou loss was far and away the worst loss of the year for me, followed by the crash to reality loss at home to Penn St after beating Texas.
If the team spirals after today's loss, then I will agree with you. Otherwise, this is simply recency bias in full motion.
Regroup and beatdown Mich, then play with nothing to lose at Purdue. Still a lot of basketball ahead, despite what doomsdayers say after a bad loss to a young OSU team.