I think our issue in the NCAAs last year was as much a lack of experience in that event as anything else. I think there is a tendency, especially when you are a very hyped #1 seed, to over-look certain opponents because of the name on the jersey.
You have to come ready for a dog fight every single possession. Be confident in what you can do, but don't under-estimate anyone... especially a mid-major. Those teams have typically won a lot of games and have experienced players. That winning mindset doesn't just go away because of your seeding.