Defensively I'd play a tempo 2-2-1 on all made baskets to kill 6-8 shot clock seconds every possession. I'd fall back primarily into man, and I think for our current personnel the pack line is the correct man defense to run. However, after we've been guarding for about 8-10 seconds, we'd switch to a zone. In late clock situations teams almost always go iso or pick and roll and a zone would help negate the effectiveness of that. If we fell back into a zone from the 2-2-1, we'd switch to man late in the clock. Everyone goes to a pick and roll and we would work extensively on ball screen defense for late clock situations in practice. Basically, since we suck at defense I'd mix them up a lot.
Offensively I'd install a motion continuity to force movement from all 5 guys, making them all a threat. I would use pick and roll and iso stuff as a change up or call it if we got a favorable matchup off a switch in our continuity. I'm a huge fan of Brad Underwood's spread offense and the interchangeability of players in it. So that's the one I would install. It also has a backside pick and roll or handoff and roll in it for good measure so if you really like those actions, which I do, you could get 2-3 opportunities per possession. Zone offense would be more of a gap attack setup than a matchup setup. For example, when we see a 2-3 we usually setup in a 4 out 1 in set. Basically turns the zone into a quasi man. However, vs a 2-3 I'd start with a 3 out 2 on the baseline (not block literally as close to ob as possible) so that our players start in position to attack gaps by flashes or dribble penetration immediately.
Rotation wise I'd probably only play 8.
TJL
JCL
Hill
Leron
Morgan
Best of Tracy/Tate
Best of Kipper/DJ/AJ
Best of Thorne/Finke
Tldr: kill shot clock and switch defenses more, install a motion continuity, play no more than 8.