Summary as of today:
Southampton will face Leeds at Wembley on 27 May for the final promotion to the Premier League. Leicester City and Ipswich Town have already gained automatic promotion.
Sheffield United and Burnley have both been relegated and Luton Town has only the slimmest of hope as they are currently 3 points behind Nottingham Forest (and -12 on goal differential). It would take a miracle for Luton to survive. Luton host Fulham while Nottingham travels to Burnley for the final match.
Probably don't need to say anything about the top 2 since I think we all know full well what that situation is.
Liverpool has locked in 3rd and Aston Villa has locked in 4th. Tottenham sit just 3 points ahead of Chelsea but have the luxury of facing bottom side Sheffield United. Chelsea, meanwhile, hosts Bournemouth. Newcastle United and Manchester United will have to battle it out for the last potential European spot as they are tied on points (Newcastle holds a 24 goal differential advantage). Newcastle travels to Brentford and Manchester United travels to Brighton & Hove Albion.
Manchester City, Arsenal, Liverpool, & Aston Villa have locked up qualification for Champions League next season. The other European spots have many permutations, also complicated by Manchester United's presence in the FA Cup final, which would see them qualify for the Europa League with a win.